Description
MTSV1-7 CE1 cell line is a clonal derivative of the human mammary luminal epithelial cell line MTSV1-7 transfected with ERBB2 expression vector, enabling the over-expression of ERBB2 proto-oncogene. Cultures of MTSV1-7 were transfected with the pSV2-erbB2 construct together with the pSV2neo plasmid. The MTSV1-7 CE1 cell line cell line cell line is an ideal tool for investigation of the role of the ERBB2 receptor proto-oncogene in breast cancer morphogenescell line cell line is and adhesion. MTSV1-7 CE1 cells over-express the ERBB2 receptor, inducing a reduced ability to undergo morphogenesis in vitro, and reduced expression of surface adhesion molecules E-Cadherin and alpha-2 integrin. Inhibition of morphogenescell line cell line is and transcription of adhesion molecules in human mammary epithelial cells can be affected by signals generated by the ERBB2 receptor, suggesting a role for ERBB2 over-expression in tumour progression and metastasis.
Adherent Suspension
Adherent
Suggested Medium
DMEM + 2mM Glutamine + 10% Foetal Bovine Serum (FBS) + Hydrocortisone (5 µg/ml) + Bovine Insulin (10 µg/ml).
Quality Control
MTSV1-7 CE1 Cell Line was tested and found to be free of mycoplasma, bacterial, viruses, and other toxins. All cells were above 95% viability before freezing.
Morphology
Cuboidal morphology at confluence
Shippment
MTSV1-7 CE1 Cell Line will be shipped using dry ice.
Storage
Store the cell lines in liquid nitrogen vapor (less than -130°C)
Warranty
MTSV1-7 CE1 Cell Line is for research use only
